Dr Samuel Furse

Post-Doctoral Researcher

Samuel Furse profile

Lipids make up a key part of all biological systems. They have fundamental roles in both the structure and supply of energy in biological systems. In the widest sense, the term ‘lipid’ refers to several, distinct areas of metabolism, including sterols and species comprising fatty acid residues. However, lipid metabolism and biophysics are some of the most complicated and least well understood in Science. I am interested in understanding the role of lipid metabolism in the health and disease of biological systems. This includes both collection of data (low, medium and high throughput lipidomics) and also analysis of those data to test hypotheses about how lipid metabolism is controlled. This includes leading a collaboration that is developing a novel network analysis tool called Lipid Traffic Analysis. LTA is designed for understanding the control of metabolism using lipidomics and metabolomics data. In bees, key questions about how bees manage their lipid metabolism obtain as they do in mammals, but more important to global sustainability through pollination is the role of nutrition in the longevity of bees. Answering questions about which nutrients are essential for bees is the principal aim of my work at Kew.

  • Postdoctoral Fellow, University of Cambridge, 2017-2020
  • Postdoctoral Fellow, University of Bergen, 2015-2017
  • Postdoctoral Fellow, University of Utrecht, 2013-2015
  • Postdoctoral Fellow, University of Nottingham, 2011-13
  • PGCE Secondary Science, Imperial College, 2011
  • Research Assistant, Imperial College, 2010
  • PhD, Chemistry and Chemical Biology, Imperial College, 2011
  • MRes, Protein and Membrane Chemical Biology, Imperial College, 2006
  • Scientist, EvotecOAI, 2004-05
  • MChem, Medicinal Chemistry, UCL 2004

Furse, S., Fernandez-Twinn, D.S., Chiarugi, D., Koulman, A. & Ozanne, S.E. (2021)

Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes.

International Journal of Molecular Sciences 22: 7452.

Furse, S., Watkins, A.J., Hojat, N. et al. (2021)

Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism.

Communications Biology 4: 163.

Vítová, M., Lanta, V., Čížková, M., Jakubec, M., Rise, F., Halskau, Ø., Bišová, K. & Furse, S. (2021) 

The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote.

Biochim Biophys Acta Mol Cell Biol Lipids 1866:158965. 

Furse, S., Williams, H.E.L., Watkins, A.J. et al. (2021)

A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies.

Anal Bioanal Chem 413: 4763–4773

Furse, S., Fernandez-Twinn, D., Jenkins, B. et al. (2020)

A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues.

Anal Bioanal Chem 412: 2851–2862