22 April 2021
I am a natural product chemist that specialises in the identification of new or known metabolites of botanical origin, that are active against pathogenic or contaminating bacteria and fungi. I am proficient at isolation using several chromatographic methods (normal and reverse phase techniques) and structural elucidation by NMR. I also perform microtiter plate broth dilution assays to determine minimum inhibitory concentrations of active metabolites against target microbial organisms.
In 2014 I obtained my PhD, which focused on the role of volatile organic compounds or essential oils in the materia medica of the Australian Aboriginal people as topical antiseptics, wound sterilisation and in chemosemiosis. I have vast botanical and chemical knowledge of Eremophila, Eucalyptus, Pittosporum and Prostanthera. In 2016-2018 I completed a postdoctoral fellowship at the University of Johannesburg in South Africa where I focused on: terpenoids from Croton, Elaeodendron, Warburgia; volatile organic compounds from Annesorhiza, Croton, Pelargonium, Pentzia; liminoids from Khaya and flavonoids/anthocyanins from various species (Banksia, Mentha, Pelargonium). Exploration of the properties of South African medicinal species was undertaken in cooperation and collaboration with Zulu practitioners and students using material sourced from muthi markets.
I joined RBG Kew in Feb 2019 to continue the process of discovery of plant-based compounds that are significant to industry for antimicrobial and dermatological end uses. My main roles include the isolation and spectroscopic/spectrometric elucidation of natural products followed by in vitro screening.
- Research Scientist Royal Botanic Gardens, Kew 2019
- Postdoctoral Fellowship, University of Johannesburg, Johannesburg, Gauteng, South Africa 2018
- Occasional lecturer, University of New England, Armidale, NSW, Australia 2016
- PhD, University of New England, Armidale, NSW, Australia 2014
- BSc Applied Science, Southern Cross University, Lismore, NSW, Australia 2007
Sadgrove, N.J., Senbill, H., van Wyk, B.E., & Greatrex, B.W. (2020).
New Labdanes with Antimicrobial and Acaricidal Activity: Terpenes of Callitris and Widdringtonia (Cupressaceae).
Antibiotics 9: 173.
Sadgrove, N.J. (2020).
Comparing essential oils from Australia's ‘Victorian Christmas Bush’ (Prostanthera lasianthos Labill., Lamiaceae) to closely allied new species: Phenotypic plasticity and taxonomic variability.
Phytochemistry 176: 112403.
Sadgrove, N.J. (2020)
Scientific African 9: e00502.
Sadgrove, N.J., Padilla-González, G.F., Telford, I.R.H., et al. (2020)
‘Prostanthera (Lamiaceae) as a ‘Cradle of Incense’: Chemophenetics of Rare Essential Oils from Both New and Forgotten Australian ‘Mint Bush’ Species.’
Plants 9: 1570.
Sadgrove, N.J., Telford, I.R.H., Padilla-González, G.F., Greatrex, B.W., & Bruhl, J.J. (2020).
GC–MS ‘chemophenetics’ on Australian pink-flowered Phebalium (Rutaceae) using herbarium leaf material demonstrates phenetic agreement with putative new species.
Phytochemistry Letters 38: 112-120.
Sadgrove, N.J. & Jones, G.L. (2019).
From petri dish to patient: Bioavailability estimation and mechanism of action for antimicrobial and immunomodulatory natural products.
Frontiers in Microbiology 10, 2470.
Sadgrove, N.J. (2018).
The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance.
Journal of Ethnopharmacology 227: 206-236.