Scientists discover how bees activate natural medicine against parasite infection during pollination
Release date: 2 May 2022
- Scientists from the Royal Botanic Gardens, Kew and partners find bees naturally activate ‘medicinal’ compounds in linden and strawberry tree nectar
- Discovery offers new possibilities for protecting bee health
- Bees play a key role as pollinators in supporting vital ecosystems and the global food chain, but face alarming rates of decline
- Researchers hope study will influence conservation efforts for bees through deeper understanding of how microbiomes affect pollinator health
In a new paper published today in a special issue of Philosophical Transactions of The Royal Society, Kew scientists and partners report on how bees activate the ‘medicinal’ properties of various nectars to protect themselves from parasite infections.
The team of researchers led by Kew scientist Dr Hauke Koch, in partnership with Professor Mark Brown at Royal Holloway, University of London, collected nectar and pollen samples from linden and strawberry trees at Kew Gardens in West London to determine how bees process the beneficial compounds found within. The researchers found that two compounds naturally found in the nectars of these species are activated by the bees’ digestive processes, the gut microbiome (microorganisms) or a combination of both.
The study’s primary aim was to discover how these elements and their antiparasitic qualities can protect bees from the common gut parasite Crithidia bombi. The experiments yielded promising results for bee conservation efforts at a time when pollinators face the increasing threat of decline from climate change, disease, and habitat loss due to agriculture and land use.
Pollination by animals is one of the world’s most important species interactions, as plants offer a nutritious reward to insects, birds, and small mammals in exchange for the transfer of pollen. Not only does this process facilitate the reproduction of many plants but it also serves to support global food production and ecosystems. Scientists are, therefore, alarmed to see mounting evidence of declines in pollinator abundance and diversity.
Among the threats faced by pollinators today are the dangers posed by parasites. Bee parasites can be introduced and spread through global trade routes, and can spill over from managed honeybee colonies to wild pollinators. Their effects on bees are worsened by other stress factors such as pesticide use affecting microbiome health. The bumblebee gut parasite C. bombi is of special interest to scientists as the parasite is common and known to threaten the survival and development of bumble colonies.
Dr Hauke Koch, Research Leader in Pollinator Biological Chemistry at RBG Kew and lead author of the paper, says: 'Pollinators have diverse microbiomes in their guts and nest environments. These communities of microorganisms can be important for the health of pollinators, for example by defending them against diseases or producing important nutrients. By better understanding the functional importance and contributions of individual members of the microbiome to different pollinators, we may in the future be able to better support their health. For example, managed honeybee and bumblebee colonies can be supported through novel probiotics, or healthy microbiomes in wild pollinators can be maintained through a restriction in pesticides that negatively affect the microbiome and through the promotion of plants with nectar or pollen chemistry that stimulate healthy microbiomes.'
The first compound analysed by the team, unedone, was found in the nectar of strawberry trees (Arbutus unedo) and was extracted from strawberry tree honey. The evergreen, shrubby tree is native to Ireland, Western Europe and the Mediterranean, and commonly planted in parks and gardens in the UK. Its nectar and pollen-rich flowers are known to be an important food for bumblebees in the autumn. Honeybees produce a bitter-tasting honey from it that is sought after around the Mediterranean.
The compound unedone was tested on C. bombi cultures grown in a lab as well as on buff-tailed bumblebee (Bombus terrestris) gynes (female bees capable of reproduction) collected at Kew in the autumn of 2018. The latter part of the experiment saw the researchers feed the bees a mix of sugar syrup and pollen over a two-week period after which their faeces were screened for parasites. Select bees were then given a treatment of sugar syrup or a treatment of unedone. The compound was found to inhibit C. bombi infections but only after interacting with the microbiome, as the initial metabolic processes in the mid-gut rendered it inactive against the parasite.
The researchers also determined that tiliaside, a compound extracted from the nectar of the linden tree, offers similar benefits to buff-tailed bumblebee workers. However, in contrast to unedone, tiliaside was found to be activated by the bees’ own digestive processes. Both compounds have been put forward as evidence of the benefits that food and microbiomes hold for protecting and strengthening pollinator health – at an individual and community level.
Professor Phil Stevenson, Head of Trait Diversity and Function at RBG Kew, and study co-author, says: 'Understanding the drivers of pollinator health – both good and bad – is critical to realising how we can best support pollination services and continue to benefit from their contributions to food production and sustaining natural ecosystems. We now know that some flowers provide better nutrition for some species while others provide bees with a natural medicine, so we can select plants for restoring degraded landscapes or crop field margins that provide multiple and tailored benefits to pollinators enhancing their health from individual through to community level.'
In addition to the dangers posed by parasites, pollinator decline is being driven by pesticide use, the intensification of agriculture, and climate change. Scientists are thus keen to better understand the natural processes that influence and affect pollinator health – both positively and negatively. These processes include the nutritional quality of pollen and nectar, the impact of parasites and the benefits of the microbiome, as well as the effects of natural bioactive compounds and landscape structure.
Stevenson adds: 'The impacts of human activities on pollinator health and decline through excessive pesticide use, climate change and agricultural intensification are now widely accepted after decades of evidence gathering.
“We now need to look for solutions and ways of sustaining diverse and healthy populations of pollinators and other insect groups. Many of these solutions can be developed through a better understanding of the natural processes that influence pollinator health. If we know how nutrition varies across the pollen of different species and which species provide the best food resources for the widest range of pollinating species, we can implement restoration programmes such as field margin planting and ecological corridors with much better accuracy to the species of importance and with long-term benefits.'
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Notes to Editors
About the Royal Botanic Gardens, Kew
The Royal Botanic Gardens, Kew is a world-famous scientific organisation, internationally respected for its outstanding collections as well as its scientific expertise in plant and fungal diversity, conservation and sustainable development in the UK and around the world. Kew Gardens is a major international and a top London visitor attraction. Kew Gardens’ 132 hectares of landscaped gardens, and Wakehurst, Kew’s Wild Botanic Garden, attract over 2.5 million visits every year. Kew Gardens was made a UNESCO World Heritage Site in July 2003 and celebrated its 260th anniversary in 2019. Wakehurst is home to Kew's Millennium Seed Bank, the largest wild plant seed bank in the world. The Kew Madagascar Conservation Centre is Kew’s third research centre and only overseas office. RBG Kew receives approximately one third of its funding from Government through the Department for the Environment, Food and Rural Affairs (Defra) and research councils. Further funding needed to support RBG Kew’s vital work comes from donors, membership and commercial activity including ticket sales.
About Royal Holloway, University of London
Royal Holloway, University of London, is ranked in the top 25 universities in the UK. Through world class research that expands minds and changes lives, the dedication of our teachers and the feel of the Royal Holloway experience, ours is a community that inspires individuals to succeed academically, socially and personally. The university was founded by two social reformers who pioneered the ideal of education and knowledge for all who could benefit. Their vision lives on today. As one of the UK’s leading research-intensive universities we are home to some of the world’s foremost authorities in the sciences, arts, business, economics and law. We are strengthened by diversity, and welcome students and academics who travel from all over the world to study and work here, ensuring an international and multi-cultural perspective within a close knit and historic campus.
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Philosophical Transactions of the Royal Society B (Biological Sciences)
Philosophical Transactions B was established in 1665, making it the first journal in the world exclusively devoted to science and, therefore, the world’s longest-running scientific journal. It was the home of Isaac Newton’s scientific work, including his first article in 1672. The journal has been publishing scientific research at the highest level for more than 350 years, including work by William Herschel, Benjamin Franklin, Michael Faraday and Charles Darwin through to Alan Turing and Stephen Hawking.