Sedum ruwenzoriense is found from 2400-4500 m above sea level on mountains in Kenya, Uganda, Ethiopia, Sudan, Rwanda and the Democratic Republic of Congo.
This species was discovered on one of the first botanical explorations of the Rwenzori Mountains in Uganda by Dr. Wollaston in 1906.
The Yellow stonecrop prefers to grow in upland heath areas generally in rock crevices. They are perennial plants with reddish stems at the base and small green succulent leaves. The succulent leaves are an important water conservation measure as rock crevices can be a very dry environment to grow in. The flowers have five bright yellow petals in a star like shape, and the fruits are small capsules with tiny seeds only 1 mm long.