Mechanistic insights into Old English plants
Plants from the Queen’s Garden at Kew have been investigated for their potential to treat auto-immune diseases.
Often lacking in natural product drug discovery are ‘mechanistic insights’; that is, insights into the events at the molecular level that are behind any effects that plant compounds have on cells or organisms. With this in mind, Tom Prescott screened 250 Old English plants from the Queen’s Garden at Kew, to search for compounds that inhibit the human enzyme calcineurin. The results have been published in the Journal of Ethnopharmacology.
Prescott, T. A. K., Veitch, N. C. & Simmonds, M. S. J. (2011). Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria. Journal of Ethnopharmacology 137: 1306–1310.
Prescott, T. A. K., Ariño, J., Kite, G. C. & Simmonds, M. S. J. (2012). Inhibition of human calcineurin and yeast calcineurin-dependent gene expression by Jasminum humile leaf and root extracts. Journal of Ethnopharmacology 140: 293-297.
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